There is something called the S.P.E.A.R., it stands for SPontaneous Enabling Accelerated Response developed by Tony Blauer.
Tony did not invent the movement, but he did bring it to the forefront of combatives type gross motor skill movements.
I will attempt to describe it. Imagine a BG (bad guy) throwing a hook punch/haymaker at you, lets say with his right hand. Using angular movement, you move into his strike with both arms raised and at a greater than 90 degree angle forward. Your left forearm impacts the inside of his right bicep while your right forearm impacts into his collar bone area. This can cause extreme pain/damage to the bicep as well as fracture the collar bone.
To follow up, the right elbow immediately does a vertical elbow strike under the chin, then hammer fist downward into the face, then horizontal elbow, then rearward elbow followed by an upper body clinch and knee spike.
Each is a gross motor skill response. The whole sequence can be done in just over a second which critically interferes with the Bg's O.O.D.A. loop.
It is the best defense I've seen/used/taught for this type of attack and requires only a minimum of training to use for effect. I hope I've explained it adequately enough to follow.
Moo Shin Do - Taekido