Dana wrote:
You can't take capitalism out of medicine today.
You just totally dissed my 4 years of academic medicine. My work on methods to quantify blood flow in heart muscle (developing an injection agent to be imaged with a sonogram), my work on blood flow in heart muscle vs. cardiac function, my work on fibrin glue (for wound repair) and my work to help cardiac surgeons assess the patency of their CABG before getting the patient off of heat-lung bypass were all funded either by the government (NIH) or nonprofit entities (American Heart Association).
Ian and I were in a rather lengthy discussion about a month ago on the use of saw palmetto for BPH. It is a "traditional" herb that has been used for quite some time, with evidence that it may be effective. (1) Pygeum and stinging nettle are also used, as are concoctions which include pumkin seed oil.
The "standard" in medicine today are Flomax (an alpha adrenoceptor antagonist in the prostate) and Proscar or finasteride (blocks conversion of testosterone to DHT). Academic urologists absolutely were interested in whether or not saw palmetto could be used to treat BPH. There's no love lost between academia and big pharma. Trust me on that one.
So yes, there have been many half-a$$ed studies of saw palmetto. Recently a proper one was run because enough European MDs were prescribing the stuff. Why? The standard in Europe is that you can use a drug so long as it's reasonably safe. It doesn't have to be effective. Nice...
Well... Turns out that - for now - a recent prosective double-blinded study shows it may not work after all. (2) The jury is still out. One criticism of the study is that an insufficient amount of the active ingredient may not have been used. (3)
Is that important to know? Of course. No man trying to fix his BPH needs to end up in the ER to get a Foley because he didn't get the treatment he really needed.
Meanwhile, there were many who SWORE the stuff worked. I for one thought it did. It just goes to show that BPH symptoms may have a big psychological component.
And is that true in musculoskeletal as well? Absofreakinlutely. Musculoskeletal has got to have the biggest mind-body connection of any of the body systems. That's why we have arts such as yoga. That's why we have (
ahem) Sanchin!
I also happen to know quite a bit about this, as I am presently chief scientist on a project where we're refining a disease classification system used to predict health care risk. Our musculoskeletal part of the classification system is the richest of all the body systems because of our extensive experience with Workman's Comp.
GEM wrote:
Watch the TV ads for Celebrex (sp).
10 seconds of possible benefits and 2.9 minutes of warnings!!! (Including the possibility of death)
And why is this true, George? Sutton's law.
Cox II inhibitors were a big, big breakthrough. Ask anyone who has benefitted from them. They practically brought Rich back from the rocking chair, and gave him years and years in the gym and time playing rough games with the Marines in Quantico.
They were successful enough that they were used by millions and millions. They generated a LOT of money.
And where there is that much money, there is the office of Dewey, Chetham, and Howe, waiting to create class action lawsuits to siphon some of it off. Ambulance chasers follow healthcare like flies follow feces because it's where the money is.
So the pharmaceutical companies engage in a process of informed consent. To the degree they can, they document every side effect they find in their studies - even if they aren't statistically significant.
Do some companies act dishonestly? Yes, about as often as human beings do in general. But they eventually get caught - and punished.
But here's the scary part, George. You are DAMN LUCKY that evidence-based, informed consent medicine tells you all the possible side effects they know about up front.
How often do you hear the herbalists telling you that their herbs can injure or kill you? If they aren't, then they are either ignorant or they are liars. The literature is riddled with case histories of people injured or killed by traditional herbal therapies - either directly or in combination with other conventional therapies.
Whenever someone tells you there is no risk in a medical treatment, think very, very seriously about turning around and walking right out the door. When you wake up in the morning and walk out the door, you are taking a risk. It's nice to be informed so you can make a choice which caters to your preferences.
Why are the herbalists getting away without informing patients of the risk involved? Partly out of ignorance (the science isn't there yet), and partly Sutton's law. In other words, they fly under the lawyer radar because there isn't any money in it for the lawyers.
When treatments become effective enough, the revenue will follow. And where there is
significant revenue...
- Bill
1. Wilt TJ et al (1998). "Saw palmetto extracts for treatment of benign prostatic hyperplasia: a systematic review". JAMA 280: 1604–1609.
2. Bent S et al (2006). "Saw Palmetto for Benign Prostatic Hyperplasia". NEJM 354: 557–566.
3. Allison Aubrey. Morning Edition: Study Casts Doubt on Saw Palmetto as Prostate Remedy. National Public Radio.